Re: Disparities in Utilization of Autologous Hematopoietic Cell Transplantation for Treatment of Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma without Cryopreservation
High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is considered the standard of care for multiple myeloma patients who are eligible for transplantation. The process of autografting comprises the following steps: control of the primary disease by using a certain induction therapeutic protocol, mobilization of stem cells, collection of mobilized stem cells by a...
متن کاملOutcomes of Salvage Autologous Versus Allogeneic Hematopoietic Cell Transplantation for Relapsed Multiple Myeloma After Initial Autologous Hematopoietic Cell Transplantation
BACKGROUND Standard therapy for multiple myeloma (MM) includes initial autologous hematopoietic cell transplantation (autoHCT1) but this is not curative and most patients will relapse. Role of salvage autoHCT2 or allogeneic HCT (alloHCT2) is undefined. METHODS MM patients who relapsed after autoHCT1 and had salvage autoHCT2 (N = 27) or alloHCT2 (N = 19) between 1995 - 2011 at our institution ...
متن کاملRe: Tandem vs single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis.
The conclusions of the meta-analysis by Kumar et al. (1) comparing single vs tandem transplantation in myeloma are compromised by serious errors and the retraction of a key study (2) included in the analysis. The main conclusion of the meta-analysis is that tandem transplantation has no benefi cial effect on overall survival (OS) or event-free survival (EFS) in myeloma. All except one of the st...
متن کاملHematopoietic Cell Transplantation for Multiple Myeloma.
BACKGROUND: Multiple myeloma (MM) is a malignant plasma cell disorder with a median survival of three years. Despite the development of numerous conventional chemotherapy regimens and interferons, there has been little progress in improving the survival of patients with MM. Very high-dose chemoradiotherapy and autologous or allogeneic hematopoietic stem cell transplantation (HSCT) can result in...
متن کاملAutologous transplantation for multiple myeloma.
Until now high-dose therapy (HDT) supported by autologous stem cell transplantation (ASCT) has been considered the standard of care for frontline therapy of multiple myeloma (MM) in younger patients with normal renal function, and MM is currently the first indication of ASCT. However, the introduction of the novel agents thalidomide, bortezomib and lenalidomide is changing the scenario in two w...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2015
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2015.03.005